simulate the evolution of nucleotide or amino acid sequences
Seq-Gen is a program that will simulate the evolution of nucleotide
or amino acid sequences along a phylogeny, using common models of the
substitution process. A range of models of molecular evolution are
implemented including the general reversible model. State frequencies
and other parameters of the model may be given and site-specific rate
heterogeneity may also be incorporated in a number of ways. Any number
of trees may be read in and the program will produce any number of data
sets for each tree. Thus large sets of replicate simulations can be
easily created. It has been designed to be a general purpose simulator
that incorporates most of the commonly used
(and computationally tractable) models of molecular sequence evolution.