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simulation tools to generate synthetic next-generation sequencing reads

ART is a set of simulation tools to generate synthetic next-generation sequencing reads. ART simulates sequencing reads by mimicking real sequencing process with empirical error models or quality profiles summarized from large recalibrated sequencing data. ART can also simulate reads using user own read error model or quality profiles. ART supports simulation of single-end, paired-end/mate-pair reads of three major commercial next-generation sequencing platforms: Illumina's Solexa, Roche's 454 and Applied Biosystems' SOLiD. ART can be used to test or benchmark a variety of method or tools for next-generation sequencing data analysis, including read alignment, de novo assembly, SNP and structure variation discovery. ART was used as a primary tool for the simulation study of the 1000 Genomes Project . ART is implemented in C++ with optimized algorithms and is highly efficient in read simulation. ART outputs reads in the FASTQ format, and alignments in the ALN format. ART can also generate alignments in the SAM alignment or UCSC BED file format. ART can be used together with genome variants simulators (e.g. VarSim) for evaluating variant calling tools or methods.

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Architektúra Verzia Veľkosť balíka Nainštalovaná veľkosť Súbory
amd64 20160605+dfsg-4+b3 1,645.8 kB9,101.0 kB [zoznam súborov]
arm64 20160605+dfsg-4+b3 1,630.6 kB9,161.0 kB [zoznam súborov]
armel 20160605+dfsg-4+b3 1,629.3 kB9,158.0 kB [zoznam súborov]
armhf 20160605+dfsg-4+b3 1,629.8 kB9,030.0 kB [zoznam súborov]
i386 20160605+dfsg-4+b3 1,648.8 kB9,122.0 kB [zoznam súborov]
mips64el 20160605+dfsg-4+b3 1,639.1 kB9,241.0 kB [zoznam súborov]
mipsel 20160605+dfsg-4+b3 1,641.2 kB9,236.0 kB [zoznam súborov]
ppc64el 20160605+dfsg-4+b3 1,643.6 kB9,417.0 kB [zoznam súborov]
s390x 20160605+dfsg-4+b3 1,636.0 kB9,093.0 kB [zoznam súborov]